On behalf of the Division, the Board manages the Journal and its associated educational activities. The Board negotiates, maintains, and implements the co-publishing agreement with the American Chemical Society through ACS Publications. The Board alone can authorize contracts with individuals and companies for services and goods and/or authorize the Editor to be responsible for such arrangements as part of the yearly operational budget of the Editorial Office. In particular, the Board maintains an agreement with the Editor (and any other management personnel the Board considers necessary) who serves for a stated term at the Board's discretion. The Board also negotiates and maintains any necessary contracts with the host institution(s) of the Journal.

The Board of Trustees of the ACS Examinations Institute is entrusted with establishing policies for all aspects of Institute operations and appointment of a Director.  The Board’s primary duties are fiduciary. Using reports from the Director and other sources, the Board monitors operating budgets, income, investments, hosting agreements, protection of intellectual property, accounting, audits, and taxes.

The Board consists of nine voting members, three of whom serve in an ex-officio capacity and six others who are appointed by the Executive Committee of DivCHED. Ex-officio members shall be: one member of the Chair's succession of the Division of Chemical Education, the Member-at-Large for the Division, and the Treasurer of the Division. Appointed members serve three-year terms and can serve multiple terms if reappointed by the Executive Committee.